Autoimmune pancreatitis (AIP) is a chronic, rare and little known inflammatory disease, which is a pancreatic expression of a recently described entity and known as IgG4-related sclerosing disease which affects multiple organs. The AIP is a benign process, however, in many cases, it is indistinguishable from pancreatic cancer by imaging techniques in which both entities appear as space-occupying lesions (SOL) of the pancreas, so differential diagnosis is important because it can avoid an unnecessary number of pancreatic resections with the morbidity and mortality they entail.
The gold standard for the differential diagnosis of both entities is the histological examination of the lesion. We report the case of a 39 year old male diagnosed with pancreatic neoplasm from imaging tests who was finally diagnosed with PAI taking into account other criteria without requiring histological confirmation.
Key words: autoimmune pancreatitis, sclerosing disease associated with Ig G4, space-occupying lesion (SOL) of the pancreas, pancreatic cancer.